Browsing Physiology (Scholarly Publications) by Title
Now showing items 56-75 of 136
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The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
(2012)Background: Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by increased microglial activation associated with ... -
Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
(2014)The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy ... -
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
(2016)Check TCD e-journals(opens in a new window)|View at Publisher| RIS export | Download | Add to List | More... Journal of Neuroinflammation Volume 13, Issue 1, February 08, 2016, Article number 31 Open ... -
From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ... -
Functional expression of serotonin 5-HT7 receptor in human glioblastoma cell lines
(2004)Serotonin 5‐HT7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. The aim of the present ... -
Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling
(The Company of Biologists Ltd, 2015)Globoid cell leukodystrophy (Krabbe disease) is a rare infantile neurodegenerative disorder. Krabbe disease is caused by deficiency in the lysosomal enzyme galactocerebrosidase (GALC) resulting in accumulation, in the ... -
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.
(2009)Background Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
(2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
(2013)Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative diseases including Alzheimer?s disease (AD) and are typified by increased microglial activation. Microglia express several receptors ... -
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
(2013)Background: Alzheimer?s Disease is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. Objective: ... -
Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.
(2018)A defining pathophysiological hallmark of Alzheimer’s disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout ... -
Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise
(2019)We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with ...