Browsing Physiology (Scholarly Publications) by Date of Publication
Now showing items 21-40 of 136
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Physiological changes following a 12 week gym based stair-climbing, elliptical trainer and treadmill running program in females
(Minerva Medica, 2004)Despite the growing popularity of the elliptical trainer aerobic exercise modality the physiological changes induced following a training program using elliptical trainers remains unknown. Donne investigates the metabolic ... -
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
(2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
Effect of body tilt on calf muscle performance and blood flow in humans
(American Physiological Society, 2005)To explore the effect of posture on muscle performance, we tested the effects of body tilt angle on the strength, endurance, and fatigue of, and blood flow into, the plantar flexors. Human subjects were fixed to a tilt ... -
The relationship of medical, demographic and psychosocial factors to direct and indirect health utility instruments in rheumatoid arthritis.
(2006)Cost-effectiveness analysis (CEA) is essential for the comparison of treatments for rheumatoid arthritis (RA). CEA centres on accurate measurement of health utility (HU) preferences. Direct measures of HU in RA patients ... -
The Schizophrenic Faces of PICK1
(2006)Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
The effect of externally generated loading on predictive grip force modulation.
(2007)A characteristic of skilled movement is the ability of the CNS to predict the consequences of motor commands. When we lift an object there is an anticipatory increase in grip force that prevents a grasped object from ... -
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.
(2009)Background Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and ... -
Design and synthesis of selective and potent orally active S1P5 agonists.
(2010)The immunomodulatory drug fingolimod (FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol), derived from a fungal metabolite (ISP-1, myriocin), is phosphorylated in vivo by sphingosine kinases to produce ... -
Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex
(2010)Evidence indicates that noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and plays a neuroprotective role where inflammatory events contribute to pathology. Here we examined the ability ...