Browsing Physiology (Theses and Dissertations) by Author "McCormack, Róisin Maureen"
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The role of the lysosomal system in beta amyloid 1-40-mediated neurodegeneration in cultured cortical neurons
McCormack, Róisin Maureen (Trinity College (Dublin, Ireland). Department of Physiology, 2007)β-amyloid (Aβ1-40) is a component of the senile plaques found in Alzheimer’s disease (AD). There is evidence that Aβ mediates its apoptotic effect through release of lysosomal proteases to the cytosol with subsequent ...