The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis
Citation:
Deborah Cluxton, 'The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 288Download Item:
Cluxton TCD THESIS 11061 The role.pdf (PDF) 111.3Mb
Abstract:
Th17 cells are important pathogenic effector cells in autoimmune diseases such as rheumatoid
arthritis (RA), psoriasis and multiple sclerosis (MS). On the other hand, regulatory T (Treg) cells
play a crucial role in maintaining tolerance and preventing autoimmunity. Under healthy
conditions there is a balance between Treg and effector T cell responses, which may be perturbed
in autoimmunity, cancer and other diseases; therefore, it is crucial to understand the factors that
regulate this balance. Recently, a role for metabolism and hypoxia in murine T cell differentiation
has been identified.
Author: Cluxton, Deborah
Advisor:
Fletcher, JeanQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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