Browsing by Subject "Oncology"
Now showing items 21-38 of 38
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Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 2.
(2009)A recent increase in the number of young patients (often nonsmokers) developing head and neck squamous cell carcinoma (HNSCC) has been documented, however, there remains no clear evidence to support the significance of any ... -
The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers.
(2009)We investigated the role of the C1772T polymorphisms in exon 12 of the Hypoxia-inducible factor-1 alpha (HIF-1alpha) gene C1772T genotype in prostate cancer (PCa) and amplification of the hypoxic response. We identified ... -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
(Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery.
(2010)Background: The association between cancer, major surgery and venous thromboembolism (VTE) is well established. Multimodal therapy is increasingly being used as standard treatment for localised gastrointestinal ... -
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
(2010)Background: Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drug efflux pumps, ... -
NF-κB regulation: The nuclear response
(2009)Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ... -
Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells
(2010)PURPOSE: The development of multi-drug resistance (MDR) due to the expression of members of the ATPase binding cassette (ABC) transporter family is a major obstacle in cancer treatment. The broad range of substrate ... -
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo
(Nature, 2010)Background: Imatinib is a direct and potent inhibitor of the constitutively active tyrosine kinase, breakpoint cluster region-Abelson (Bcr-Abl), which is central to the pathogenesis of chronic myeloid leukaemia (CML) ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
(2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue
(2011)Obesity has been associated with increased incidence and mortality of oesophageal and colorectal adenocarcinoma. Excess central adiposity may drive this association through an altered inflammatory milieu. Utilizing a unique ... -
Receptor tyrosine kinases and their activation in melanoma.
(2011)Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of Exercise Prehabilitation Prior to Oncological Resection
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)Cancer is characterised by uncontrolled cell growth within the body. Surgical resection is the primary curative treatment for solid tumours. However, surgery is invasive and associated with significant morbidity and ... -
Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening
(2011)A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly ... -
Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6
(2011)Toll-like receptors (TLRs) modulate the expression of multiple microRNAs (miRNAs). Here we report the down-regulation of miR-107 by TLR4 in multiple cell types. The miR-107 sequence occurs in an intron within the sequence ... -
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
(2009)The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide polymorphism ... -
Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis.
(Nature, 2011)P53 inactivation is often observed in Burkitt's lymphoma (BL) cells due to mutations in the p53 gene or overexpression of its negative regulator, murine double minute-2 (MDM2). This event is now considered an essential ...