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Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids
(2013)
The unintentional generation of amorphous character in crystalline active pharmaceutical ingredients (APIs) is an adverse consequence of mechanical activation during dosage form manufacture. In this study, we assess and ...
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)
Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler.
In the present study we sought to examine the feasibility of producing nanoporous ...
Dry powders for oral inhalation free of lactose carrier particles
(2014)
Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues ...
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)
The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ...
Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose
(2015)
PURPOSE:
To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars ...
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)
This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ...
Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
(2013)
Developing amorphous pharmaceuticals can be desirable due to advantageous biopharmaceutical properties. Low glass transition temperature (Tg) amorphous drugs can be protected from crystallisation by mixing with high Tg ...
Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid
(2013)
Multi-ionisable compounds, such as dicarboxylic acids, offer the possibility of forming
salts of drugs with multiple stoichiometries. Attempts to crystallise ciprofloxacin, a
poorly water soluble, amphoteric ...