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Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid
(2013)
Multi-ionisable compounds, such as dicarboxylic acids, offer the possibility of forming
salts of drugs with multiple stoichiometries. Attempts to crystallise ciprofloxacin, a
poorly water soluble, amphoteric ...
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)
The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ...
Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia.
(2013)
The oil of babassu tree nuts (Orbignya speciosa) is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. ...
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)
Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler.
In the present study we sought to examine the feasibility of producing nanoporous ...
Dry powders for oral inhalation free of lactose carrier particles
(2014)
Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues ...