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Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt
(Wiley, 2011)
The production of salt or cocrystalline forms is a common approach to alter
the physicochemical properties of pharmaceutical compounds. The goal of this work was to
evaluate the impact of anion choice (succinate, adipate, ...
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure
(Elsevier, 2010)
Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state ...
Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers
(2014)
This work investigates a new type of polyelectrolyte complex nanocarrier composed of hyaluronic acid (HA) and protamine (PROT). Small (approximately 60 nm) and negatively charged nanoparticles (NPs) with a polydispersity ...
Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole.
(2014)
traconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug's apparent ...