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Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
(2013)
Developing amorphous pharmaceuticals can be desirable due to advantageous biopharmaceutical properties. Low glass transition temperature (Tg) amorphous drugs can be protected from crystallisation by mixing with high Tg ...
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)
This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ...
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery
(2013)
In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of ...
Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid
(2013)
Multi-ionisable compounds, such as dicarboxylic acids, offer the possibility of forming
salts of drugs with multiple stoichiometries. Attempts to crystallise ciprofloxacin, a
poorly water soluble, amphoteric ...
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)
The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ...
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)
Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler.
In the present study we sought to examine the feasibility of producing nanoporous ...