Browsing Pharmacy and Pharmaceutical Sciences by Sponsor "Irish Research Council (IRC)"
Now showing items 1-14 of 14
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Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs).
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)This project aims to develop a drying protocol that removes unwanted moisture from hydrated APIs while preserving water of hydration. Hydrate forms of model compounds, carbamazepine and theophylline, were generated with ... -
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
(2021)To study and exploit extracellular vesicles (EVs) for clinical benefit as biomarkers, therapeutics, or drug delivery vehicles in diseases such as cancer, typically we need to separate them from the biofluid into which they ... -
Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?
(2020)Extracellular vesicles (EVs), often described as mini-maps of their cells of origin, are found in the bloodstream and can be rich sources of cargo released from cancer cells. As such, they could be collected through minimally ... -
Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation.
(2020)MET pathway is an important actionable target across many solid tumour types and several MET inhibitors have been developed. Extracellular vesicles (EVs) are proposed to be mini-maps of their cells of origin. However, the ... -
Inhibiting extracellular vesicles formation and release: a review of EV inhibitors.
(2019)It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell-to-cell communication, both in physiological and pathological conditions. Once outside the cell, these ... -
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications
(2020)Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in tissue engineering and regenerative medicine. However, recent evidence suggests that the beneficial effects of MSCs may be manifest ... -
A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker
(2022)Extracellular vesicles (EVs) have potential as minimally invasive biomarkers. However, the methods most commonly used for EV retrieval rely on ultracentrifugation, are time-consuming, and unrealistic to translate to ... -
Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey
(2021)To develop and subsequently get cancer researchers to use organotypic three-dimensional (3D) models that can recapitulate the complexity of human in vivo tumors in an in vitro setting, it is important to establish what in ... -
The production of crystalline powders by spray drying to improve the mechanical and flow properties of an active pharmaceutical ingredient
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The overall aim of this research was to crystallise a drug onto the surface of an excipient (EXP) using a spray dryer in order to improve the processability of the attached active pharmaceutical ingredient (API). The project ... -
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
(2021)The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was ...