Browsing Pharmacy and Pharmaceutical Sciences by Author "O'BRIEN, JOHN EUGENE"
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Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures
O'BRIEN, JOHN EUGENE; HEALY, ANNE MARIE; TAJBER, LIDIA; CORRIGAN, OWEN; MC CABE, THOMAS; PALUCH, KRZYSZTOF (Elsevier, 2011)Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility ... -
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure
TAJBER, LIDIA; MC CABE, THOMAS; HEALY, ANNE MARIE; O'BRIEN, JOHN EUGENE; CORRIGAN, OWEN; PALUCH, KRZYSZTOF (Elsevier, 2010)Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state ...