Browsing Pharmacy and Pharmaceutical Sciences by Author "HEALY, ANNE"
Now showing items 1-20 of 28
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Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery
EHRHARDT, CARSTEN; HEALY, ANNE (2016) -
Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling
HEALY, ANNE (2013)The aim of this paper is to investigate the physicochemical properties of binary amorphous dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling. The sulfonamides selected were sulfathiazole ... -
Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
TAJBER, LIDIA; HEALY, ANNE (2013)Developing amorphous pharmaceuticals can be desirable due to advantageous biopharmaceutical properties. Low glass transition temperature (Tg) amorphous drugs can be protected from crystallisation by mixing with high Tg ... -
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
HEALY, ANNE; CORRIGAN, OWEN; TAJBER, LIDIA; GROSSJOHANN, CHRISTINE (2012)This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ... -
Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose
TAJBER, LIDIA; HEALY, ANNE (2015)PURPOSE: To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars ... -
Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation
HEALY, ANNE (2016)In the present study, in vitro permeation experiments in a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine (RV) transdermal drug delivery system. ... -
Comparative study of different methods for the prediction of drug-polymer solubility
TAJBER, LIDIA; HEALY, ANNE (2015) -
Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate
HEALY, ANNE (2016)he purpose of this study was to prepare engineered particles of rivastigmine hydrogen tartrate (RHT) and to characterize the physicochemical and aerodynamic properties, in comparison to a lactose carrier formulation (LCF). ... -
Dry powders for oral inhalation free of lactose carrier particles
TAJBER, LIDIA; HEALY, ANNE (2014)Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues ... -
Emerging nanonisation technologies: tailoring crystalline versus amorphous nanomaterials
HEALY, ANNE (2015)The overall pharmaceutical market is changing. A more personalised medicine approach is replacing the concept of blockbuster drugs and the “one size fits all” model. The two main forces that fuel the growth of nano-enabled ... -
Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid
TAJBER, LIDIA; HEALY, ANNE (2013)Multi-ionisable compounds, such as dicarboxylic acids, offer the possibility of forming salts of drugs with multiple stoichiometries. Attempts to crystallise ciprofloxacin, a poorly water soluble, amphoteric ... -
Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation
EHRHARDT, CARSTEN; HEALY, ANNE (2015) -
Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials
HEALY, ANNE; AMARO, MARIA INES; TAJBER, LIDIA; PALUCH, KRZYSZTOF; CORRIGAN, OWEN (2012) -
Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System
HEALY, ANNE; TAJBER, LIDIA; CORRIGAN, OWEN; PALUCH, KRZYSZTOF (2012) -
Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals
HEALY, ANNE; D'ARCY, DEIRDRE; PERSOONS, TIM (2016)Purpose: The aim of this work was to evaluate the influence of crystal habit on the dissolution and in vitro antibacterial and anitiprotozoal activity of sulfadimidine:4-aminosalicylic acid cocrystals. Methods: Cocrystals ... -
Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol
HEALY, ANNE; FRANKISH, NEIL (2015)The single enantiomer (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2), has recently been synthesized and isolated from its corresponding diastereoisomer (1). The molecular and crystal structures of this ... -
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
CORRIGAN, OWEN; HEALY, ANNE; TAJBER, LIDIA; AMARO, MARIA INES (2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine
TAJBER, LIDIA; SASSE, ASTRID; HEALY, ANNE (2017) -
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
HEALY, ANNE; CORRIGAN, OWEN; TAJBER, LIDIA (2011)The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ...