Browsing Pharmacy and Pharmaceutical Sciences by Author "HARKIN, ANDREW"
Now showing items 1-3 of 3
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Exaggerated increases in microglia proliferation, brain inflammatory response and sickness behaviour upon lipopolysaccharide stimulation in non-obese diabetic mice
HARKIN, ANDREW; McGuiness, Barry; Gibney, Sinead M.; Beumer, Wouter; Versnel, Marjan A.; Sillaber, Inge; Drexhage, Hemmo A. (2016)The non-obese diabetic (NOD) mouse, an established model for autoimmune diabetes, shows an exaggerated reaction of pancreas macrophages to inflammatory stimuli. NOD mice also display anxiety when immune-stimulated. Chronic ... -
The PSD-95/nNOS Complex: New Drugs for Depression?
DOUCET, MARIKA; HARKIN, ANDREW; DEV, KUMLESH (2012)Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically ... -
Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1
HARKIN, ANDREW (2015)Strong evidence showed neurotoxic properties of beta amyloid (Aβ) and its pivotal role in the Alzheimer's disease (AD) pathogenesis. Beside, experimental data suggest that Aβ may have physiological roles considering that ...