Browsing Obstetrics & Gynaecology by Author "O'Leary, John"
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Circulating tumour cells: The Good, the Bad and the Ugly.
Ward, Mark; O'Toole, Sharon; O'Leary, John; Malone, Victoria; O'Connor, R?is?n (2023)This review is an overview of the current knowledge regarding circulating tumour cells (CTCs), which are potentially the most lethal type of cancer cell, and may be a key component of the metastatic cascade. The clinical ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
Norris, Lucy; Martin, Cara; O'Leary, John; Finn, Stephen; O'Toole, Sharon; Sheils, Orla; Abu Saadeh, Feras; Flavin, Richard; Kelly, Lynne (2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ...