Browsing RSS Feeds by Sponsor "Medical Research Council (MRC)"
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Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
(2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility ... -
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
(2012)Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 ... -
The Influence of Central Neuropathic Pain in Paraplegic Patients on Performance of a Motor Imagery Based Brain Computer Interface
(2015)Objective The aim of this study was to test how the presence of central neuropathic pain (CNP) influences the performance of a motor imagery based Brain Computer Interface (BCI). Methods In this electroencephalography ... -
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
(Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
(2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ...