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2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
(Portland Press, 1997)The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B). In agreement ... -
Adapting developing country epidemiological assessment techniques to improve the quality of health needs assessments in developed countries
(BioMed Central, 2005)Background: We were commissioned to carry out three health assessments in urban areas of Dublin in Ireland. We required an epidemiologically robust method that could collect data rapidly and inexpensively. We were dealing ... -
Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
(Elsevier, 2009)Healthy aging is associated with brain volume reductions that involve the frontal cortex, but also affect other brain regions. We sought to identify an age-related network pattern of MRI gray matter using a multivariate ... -
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa.
(BioMed Central, 2007)Background The role played by microRNAs (miRs) as common regulators in physiologic processes such as development and various disease states was recently highlighted. Retinitis pigmentosa (RP) linked to RHO (which encodes ... -
Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser.
(BioMed Central, 2010)Background: Candida species are the most common cause of opportunistic fungal infection worldwide. Recent sequencing efforts have provided a wealth of Candida genomic data. We have developed the Candida Gene Order Browser ... -
Anti-malarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds
(University of Chicago Press, 2005)The polyketide macrolactone FK506 inhibits the growth of Plasmodium falciparum in culture and the enzymatic (peptidyl-prolyl cis-trans isomerase [PPIase]) and chaperone activities of a recently identified P. falciparum ... -
Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia
(Elsevier, 2008)Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies ... -
Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder (ADHD)
(2005)A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with ADHD and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the attention deficit in ADHD includes a subtle ... -
Benzodiazepine usage in the North Eastern Health Board region of the Republic of Ireland
(2004)Introduction: Benzodiazepines are a large group of drugs used as hypnotics, anxiolytics, and tranquillisers, anti convulsants, pre-medication and for intravenous sedation. Extended use of benzodiazepines may lead to ... -
Biomechanics of ossiculoplasty
(Rila, 2003)Many different designs of prostheses are available for middle ear surgery. Clinical comparisons of such prostheses are often difficult because of the large number of variables involved in the clinical outcome; including ... -
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens
(British Society for Immunology, 2000)Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also ... -
CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis.
(The American Association of Immunologists, 2009)CD11c+CD8?+ and CD103+ DC have been shown to promote regulatory T cell responses and mediate tolerance in the gastrointestinal tract. These cells have also been identified in the lung, but their role in immunity to ... -
Characteristics of opiate users presenting for a new treatment episode: Baseline data from the national treatment outcome study in Ireland (ROSIE)
(Taylor and Francis, 2007)Aim: The Research Outcome Study in Ireland (ROSIE) is the first large-scale, prospective, multi-site, drug treatment outcome study in Ireland. Method: Using a structured questionnaire, the substance use, health, crime ... -
Characterization of CD44 induction by IL-1: a critical role for Egr-1
(The American Association of Immunologists, 1999)he adhesion molecule CD44 is a multifunctional, ubiquitously expressed glycoprotein that participates in the process of leukocyte recruitment to sites of inflammation and to their migration through lymphatic tissues. In ... -
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.
(American Society for Clinical Nutrition, 2005)Background: Little is known about the interactions between choline and folate and homocysteine metabolism during pregnancy despite the facts that pregnancy places considerable stress on maternal folate and choline stores ... -
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
(Nature Publishing Group, 2008)To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also ... -
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
(Nature, 2001)The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares ... -
Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
(American Psychiatric Association, 2005)OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism ... -
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population.
(Nature Publishing Group, 2006)The risk of neural tube defects (NTDs) is known to have a significant genetic component that could act through either the NTD patient and/or maternal genotype. The success of folic acid supplementation in NTD prevention ... -
The contribution of qualitative research in designing a complex intervention for secondary prevention of coronary heart disease in two different healthcare systems
(BioMed Central, 2006)Background Developing complex interventions for testing in randomised controlled trials is of increasing importance in healthcare planning. There is a need for careful design of interventions for secondary prevention of ...