Browsing School of Engineering by Author "Mahon, Olwyn R."
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Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages
Kelly, Daniel; Shanley, Lianne C.; Mahon, Olwyn R.; Dunne, Aisling (2021)Tissue healing and regeneration is a complex, choreographed, spatiotemporal process involving a plethora of cell types, the activity of which is stringently regulated in order for effective tissue repair to ensue post ... -
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
Kelly, Daniel; Mahon, Olwyn R.; McCarthy, Geraldine M.; Dunne, Aisling (2019)Objective: A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprog-ramming of immune ... -
Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
Kelly, Daniel; Dunne, Aisling; Cunniffe, Gráinne M.; Díaz-Payno, Pedro J.; Sheehy, Eamon J.; Critchley, Susan E.; Almeida, Henrique V.; Pitacco, Pierluca; Carroll, Simon F.; Mahon, Olwyn R.; Levingstone, Tanya J.; Moran, Conor J.; Brady, Robert T.; O'Brien, Fergal J.; Brama, Pieter A.J. (2019)Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can enhance tissue-specific differentiation of adult stem cells, ...