Regional and temporal variations in tissue sodium concentration during the acute stroke phase
Citation:
Wetterling, F., Gallagher, L., Macrae, I. M., Junge, S. and Fagan, A. J., Regional and temporal variations in tissue sodium concentration during the acute stroke phase, Magnetic Resonance in Medicine, 67, 3, 2012, 740 - 749Download Item:
Abstract:
A technique for noninvasively quantifying the concentration of
sodium (23Na) ions was applied to the study of ischemic
stroke. 23Na-magnetic resonance imaging techniques have
shown considerable potential for measuring subtle changes
in ischemic tissue, although studies to date have suffered primarily
from poor signal/noise ratio. In this study, accurate
quantification of tissue sodium concentration (TSC) was
achieved in 23Na images with voxel sizes of 1.2 mL acquired in
10 min. The evolution of TSC was investigated from 0.5 to 8 h
in focal cortical and subcortical ischemic tissue following permanent
middle cerebral artery occlusion in the rat (n 5 5).
Infarct volumes determined from TSC measurements correlated
significantly with histology (P 5 0.0006). A delayed linear
model was fitted to the TSC time course data in each voxel,
which revealed that the TSC increase was more immediate
(0.2 6 0.1 h delay time) in subcortical ischemic tissue,
whereas it was delayed by 1.6 6 0.5 h in ischemic cortex (P 5
0.0002). No significant differences (P 5 0.5) were measured
between TSC slope rates in cortical (10.2 6 1.1 mM/h) and
subcortical (9.7 6 1.1 mM/h) ischemic tissue. The data suggest
that any TSC increase measured in ischemic tissue indicates
infarction (core) and regions exhibiting a delay to TSC
increase indicate potentially salvageable tissue
(penumbra).
Sponsor
Grant Number
Science Foundation Ireland (SFI)
05/RFP/PHY006
Author's Homepage:
http://people.tcd.ie/fagananhttp://people.tcd.ie/wetterf
Description:
PUBLISHED
Author: WETTERLING, FRIEDRICH; FAGAN, ANDREW
Type of material:
Journal ArticleCollections
Series/Report no:
Magnetic Resonance in Medicine67
3
Availability:
Full text availableSubject (TCD):
Neuroscience , Next Generation Medical DevicesDOI:
http://dx.doi.org/10.1002/mrm.23031Metadata
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