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Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ...
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ...
The modulation of S1P receptor signalling and demyelination
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)
Sphingosine 1-phosphate receptors are a family of G-protein coupled receptors (GPCRs) that consists of five subtypes (S1PR1-5). These receptors have emerged as therapeutic targets in multiple sclerosis (MS) due to the ...
Investigating protein and gene biomarker expression, specifically chemokine (C-X-C motif) ligand 16 (CXCL16), associated with cardiovascular diseases using a combination of in vitro and in vivo techniques
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
A patient based study was designed to analyze serum concentrations of 10 known inflammatory markers, GM-CSF, IFN-γ, IL-10, IL-12p70,IL-1β, IL-2, IL-6, IL-8, TNF-a and CXCL16 in asymptomatic and symptomatic pre-operative ...
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)
Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ...
Neuroimmune activation in arthritic and neuropathic low back pain : implications for interventional therapies
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)
Chronic pain involves a progressive disturbance of mood, sleep and physical function, with significant medical, social and economic consequences. The mechanism by which acute pain may become chronic and refractory to ...
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)
This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ...
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)
Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ...
Health care delivery, access and utilisation in emerging communities and urban slums of south west Nigeria
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2014)
In Nigeria, over 60 percent of the population lack access to modern health care facilities. Low access and effective utilisation even where available, are affected by inadequate health workforce, low quality of care, ...
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ...