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Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.
(2014)
The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects ...
Evidence that duplications of 22q11.2 protect against schizophrenia.
(2014)
A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 ...
Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
(2014)
Background:
Neural tube defects (NTDs), which are among the most common congenital malformations, are
influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor,
making ...
Effects of MIR137 on fronto-amygdala functional connectivity.
(2014)
MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ...
Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium/endothelium interface.
(2014)
The initial stages of the interaction between the host and Aspergillus fumigatus at the alveolar surface of the human lung are critical in the establishment of aspergillosis. Using an in vitro bilayer model of the alveolus, ...