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Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
(2014)
Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an essential process in both wound healing and ...
Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups.
(2014)
von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in ...
Economic impact of hospital inpatient palliative care consultation: review of current evidence and directions for future research.
(2014)
BACKGROUND:
Maintaining the recent expansion of palliative care access in the United States is a recognized public health concern. Economic evaluation is essential to validate current provision and assess the case for ...
Stroke in young women: An interpretative phenomenological analysis.
(2014)
Stroke among adults of working age is increasing. We aimed to explore the experience of stroke among young women in Ireland. In total, 12 women (aged between 18 and 50 years) participated in semi-structured interviews. ...
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)
Abstract
Introduction
There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ...
IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
(2014)
Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to ...
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
(2014)
BACKGROUND:
Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation ...
Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke.
(2014)
The impact of commencing or changing antiplatelet therapy on von Willebrand factor antigen (VWF:Ag) and von Willebrand factor propeptide (VWF:Ag II) levels has not been comprehensively assessed following TIA or ischaemic ...
Inappropriate prescribing in older fallers presenting to an Irish emergency department.
(2014)
BACKGROUND:
certain medications increase falls risk in older people.
OBJECTIVE:
to assess if prescribing modification occurs in older falls presenting to an emergency department (ED).
DESIGN:
before-and-after ...