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Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
(2014)
Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus ...
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ...
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)
Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ...
Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations
(2014)
Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), ...
The modulation of S1P receptor signalling and demyelination
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)
Sphingosine 1-phosphate receptors are a family of G-protein coupled receptors (GPCRs) that consists of five subtypes (S1PR1-5). These receptors have emerged as therapeutic targets in multiple sclerosis (MS) due to the ...
Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
(2014)
Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ...
Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.
(2014)
In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior nares of 20-80% of the human population. The relationship between host and microbe appears particularly individualized and ...
Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.
(2014)
The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects ...