Browsing School of Medicine by Author "Ravi, Narayanasamy"
Now showing items 1-14 of 14
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Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
Lysaght, Joanne; Ravi, Narayanasamy; Reynolds, John; Conroy, Melissa (2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
Ravi, Narayanasamy; Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh; Phelan, James (2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett?s esophagus compared to esophageal adenocarcinoma
Phelan, James; Reynolds, John; Ravi, Narayanasamy (2019)Barrett’s esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. ... -
Eosinophilic ascites with marked peripheral eosinophilia: a diagnostic challenge.
Ravi, Narayanasamy; Reynolds, John; Conlon, Niall; Elliott, Jessie (2014)Eosinophilic disease of the gastrointestinal tract is rare and is characterized by the presence of gastrointestinal symptoms in association with eosinophilic infiltration of any part of the gastrointestinal tract. Clinical ... -
Epstein-Barr virus-positive mucocutaneous ulcer: A unique case occurring in association with cholelithiasis in a gallbladder
Flavin, Richard; Ravi, Narayanasamy (2020)Epstein-Barr virus (EBV)-positive mucocutaneous ulcer is a lymphoproliferative disorder occurring in patients due to iatrogenic or age-related immunosuppression confined to the oropharynx, skin, and gastrointestinal tract. ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
Ravi, Narayanasamy (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Incarcerated thoracic gastric herniation after nephrectomy: a report of two cases.
Ravi, Narayanasamy; Reynolds, John; Elliott, Jessie (2013) -
Incidence and Impact of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients with Adenocarcinoma of the Esophagus Treated with Curative Intent
Lysaght, Joanne; Ravi, Narayanasamy; Reynolds, John; Elliott, Jessie; Conroy, Melissa (2022)Background and aims: Esophageal adenocarcinoma (EAC) is associated with visceral obesity (VO). Non-alcoholic fatty liver disease (NAFLD) is common within this phenotype; however, its incidence and clinical significance in ... -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
Dunne, Margaret; Lynam-Lennon, Niamh; O'Sullivan, Jacintha; Ravi, Narayanasamy (2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study
Ravi, Narayanasamy; Reynolds, John; Hennessy, Martina (2021)Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Dunne, Margaret; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ... -
Oesophageal manometry: 10-year audit from a specialist centre, and early experience with high-resolution manometry.
Reynolds, John; Ravi, Narayanasamy (2014) -
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Ravi, Narayanasamy (2020)Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however ...