Browsing School of Medicine by Author "Lavelle, Edward"
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
Lavelle, Edward; Bowie, Andrew; Carty, Michael; Fallon, Padraic; Munoz-Wolf, Natalia (2019)Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β ... -
IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
Lavelle, Edward; Gardiner, Clair; Campbell, Matthew; Humphries, Peter; Fallon, Padraic; Humphries, Marian; Doyle, Sarah; Brennan, Kiva (2014)Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to ...