Browsing School of Medicine by Author "KEANE, JOSEPH"
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Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program.
KEANE, JOSEPH; O'FARRELLY, CLIONA (2008)BACKGROUND: Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent of high throughput genomics ... -
A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection.
O'SULLIVAN, MARY; O'LEARY, SEONADH; KEANE, JOSEPH (2007)Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation. The ... -
Extensively drug-resistant tuberculosis: first report of a case in Ireland
KEANE, JOSEPH (2008)Extensively drug-resistant tuberculosis (XDR-TB) is an emerging global threat. Between 2002 and 2007 sixteen countries in the European Union (EU) reported at least one case of XDR-TB [1]. Infection is characterised by ... -
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells.
KEANE, JOSEPH; O'SULLIVAN, MARY (2011)BACKGROUND: Dendritic cells (DCs) connect innate and adaptive immunity, and are necessary for an efficient CD4+ and CD8+ T cell response after infection with Mycobacterium tuberculosis (Mtb). We previously described the ... -
Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages.
KEANE, JOSEPH; O'SULLIVAN, MARY (2017) -
A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis
KEANE, JOSEPH (PLoS, 2011)Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, we provide evidence for ... -
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing
KEANE, JOSEPH; O'SULLIVAN, MARY; Lawlor, Ciaran; O'Connor, Gemma; O'Leary, Seonadh; Gallagher, Paul J.; Cryan, Sally-Ann (2016)The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has increased the urgency to develop novel treatment modalities, ... -
Untreated Chronic Tuberculous Salpingitis followed by successful IVF Conception and Congenital Tuberculosis.
KEANE, JOSEPH; KEANE, JOSEPH (2015)Female reproductive tract tuberculosis is rare in the developed world and its diagnosis is challenging. However, this case illustrates the importance of including female reproductive tract tuberculosis in the differential ...