Browsing School of Medicine by Author "Fallon, Padraic"
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Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor
Amu, Sylvie; Fallon, Padraic (2020)The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. ... -
Btk regulates macrophage polarization in response to lipopolysaccharide.
Fallon, Padraic; Brennan, Kiva (2014)Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer ... -
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
Lavelle, Edward; Bowie, Andrew; Carty, Michael; Fallon, Padraic; Munoz-Wolf, Natalia (2019)Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β ... -
Identification of a functioning mitochondrial uncoupling protein 1 in thymus
Fallon, Padraic; Porter, Richard (2005)We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies ... -
IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
Lavelle, Edward; Gardiner, Clair; Campbell, Matthew; Humphries, Peter; Fallon, Padraic; Humphries, Marian; Doyle, Sarah; Brennan, Kiva (2014)Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to ... -
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
Walsh, Patrick; Long, Aideen; Fallon, Padraic (2022)IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate ... -
Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
Voorheis, Howard; Fallon, Padraic; Porter, Richard; Nolan, Derek (2008)The aim of this study was to demonstrate the constitutive expression of mitochondrial uncoupling protein 1 (UCP 1) in pure thymocytes using laser scanning confocal microscopic imagery. To that end we probed thymocytes from ... -
Innate lymphoid cells and parasites: Ancient foes with shared history
Fallon, Padraic; Neill, Daniel R. (2018)This special issue of Parasite Immunology charts the rapid advances made in our understanding of the myriad interactions between innate lymphoid cells and parasites and how these interactions have shaped our evolutionary ... -
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
Walsh, Patrick; Doyle, Sarah; Fallon, Padraic (2019)Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a ... -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
Volkov, Yuri; Kelleher, Dermot; Long, Aideen; Fallon, Padraic; Verma, Navin K.; Dempsey, Eugene; Davies, Anthony; Barry, Sean P. (2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Fallon, Padraic; Knolle, Martin D.; Chin, Shau Bing; Rana, Batika M.J.; Englezakis, Alexandros; Nakagawa, Rinako; Git, Anna; McKenzie, Andrew N.J. (2018)Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of type-2 immune responses, predominantly through their production of the type-2 cytokines IL-5, IL-9, and IL-13. ILC2 are essential ... -
Mitochondrial uncoupling protein 1 expression in thymocytes.
Fallon, Padraic; Porter, Richard (2008)Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out ... -
MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Fallon, Padraic; Corr, Sinead; Johnston, Daniel (2014)Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial barrier integrity in the gut. The protein MyD88 adaptor-like ... -
Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
Fallon, Padraic; Schwartz, Christian (2018)Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail ... -
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
Fallon, Padraic; Mc Manus, Ross; Hams, Emily (2015)Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to ... -
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
Fallon, Padraic; Halim, Timotheus Y.F.; Rana, Batika M.J.; Walker, Jennifer; Kerscher, Bernhard; Knolle, Martin D.; Jolin, Helen E.; Serrao, Eva M.; Haim-Vilmovsky, Liora; Teichmann, Sarah A.; Rodewald, Hans-Reimer; Botto, Marina; Vyse, Timothy J.; Li, Zhi; Withers, David R.; McKenzie, Andrew N.J. (2018)The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate ... -
Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ?? T Cells.
Walsh, Patrick; Fallon, Padraic (2013)Expression of the orphan receptor Toll IL-1R8/single Ig IL-1–related receptor has been reported to be reduced in the peripheral blood of psoriatic arthritis patients. However whether TIR8/SIGIRR activity plays a specific ...