Browsing School of Medicine by Title
Now showing items 3144-3151 of 3151
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An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter.
(2010)X11? is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding (PTB) domain to inhibit production of A? peptide that is deposited in Alzheimer's ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
(2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ... -
`You can change your life through sports' physical activity interventions to improve the health and well-being of adults experiencing homelessness: a mixed-methods systematic review
(2024)Objectives: Systematically synthesise evidence of physical activity interventions for people experiencing homelessness (PEH). Design: Mixed-methods systematic review. Data sources: EMBASE, Web of Science, CINAHL, ... -
Young people in drug treatment: their views on substance use - aetiology, trajectory, parents? role in drug use and coping skills.
(2015)Objectives: The aim of the current study was to gain insight into the process of initiation and progression to problematic use among young people who reach clinically significant levels of substance use requiring ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
(Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ... -
β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ...
