Browsing School of Medicine by Title
Now showing items 3078-3097 of 3151
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Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts
(2017)The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted ... -
Validation of the self-reported hearing questions in the Irish Longitudinal Study on Ageing against the Whispered Voice Test.
(2014)BACKGROUND: Self report questions are often used in population studies to assess sensory efficacy and decline. These questions differ in their validity in assessing sensory impairment depending on the wording of the ... -
Validation of two risk prediction models for recurrent falls in the first year after stroke: A prospective cohort study
(2017)Background: several multivariable models have been derived to predict post-stroke falls. These require validation before integration into clinical practice. The aim of this study was to externally validate two prediction ... -
The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report.
(BioMed Central, 2010)Blue rubber bleb naevus syndrome is a rare vascular disorder associated with multiple gastrointestinal haemangiomas that have the potential for life-threatening haemorrhage. These may be difficult to diagnose, and have ... -
Variability and agreement of frailty measures and risk of falls, hospital admissions and mortality in TILDA
(2022)Little is known about the within-person variability of different frailty instruments, their agreement over time, and whether use of repeat assessments could improve the strength of associations with adverse health outcomes. ... -
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
(2014)IMPORTANCE We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), ... -
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
(2010)Objective: A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of ... -
Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
Variation in DNA repair genes XRCC3, XRCC4, and XRCC5 and susceptibility ot myeloma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2010)Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that regulates maturation of the ... -
Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study.
(2008)BACKGROUND: population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as risk factors for cognitive ... -
Vascular correlates of cognitive performance in a community based elderly population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as a risk factor for cognitive dysfunction ... -
Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism
(2017)Context: Intestinal cholesterol metabolism is important in influencing postprandial lipoprotein concentrations, and might be important in the development of vascular disease. Objective: This study evaluated associations ... -
Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
(2001)Tumour progression is regulated by the balance of proliferation and apoptosis in the tumour cell population. To date, the role of vascular endothelial growth factor (VEGF) in tumour growth has been attributed to the induction ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
(2015)BACKGROUND: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
(2015)Background: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ... -
Vascular gait dyspraxia
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Vasovagal Syncope in the older adult
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)Vasovagal Syncope (VVS) is a common form of neurally mediated syncope which affects at least one third of the population at least once in their lifetime. Commonly referred to as a “simple faint” and often described as ...