Browsing School of Medicine by Title
Now showing items 3033-3052 of 3151
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Ultrasound to enhance assessment of the fetal head position prior to instrumental delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2013)This thesis is aimed at investigating the role of ultrasound to enhance diagnosis of the fetal head position prior to instrumental delivery in order to make instrumental deliveries safer.There are four components to this ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
(2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Unconventional T cells - New players in antifungal immunity
(2021)Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire ... -
Uncoupling protein 2 polymorphisms as risk factors for NTDs
(2009)Both environmental and genetic factors are involved in the etiology of neural tube defects (NTDs). Inadequate folate intake and obesity are important environmental risk factors. Several folate-related genetic variants have ... -
Undernutrition in inactive and mildly active Crohn's Disease : an unrecognised problem?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Crohn's disease (CD), the incidence of which is increasing worldwide, is a chronic transmural inflammatory disease that can affect any part of the gastrointestinal tract. It follows a relapsing remitting course and results ... -
Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics
(2020)Almost 140 years after its discovery, tuberculosis remains the leading infectious cause of death globally. For half a century, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and ... -
Understanding Change in Complex Health Systems -a review of the literature on change management and social care 2007 - 2017
(2018)A review of the change management literature underpinning the Health Services Executive (HSE) formal Change Guide, People's Needs Defining Change - Health Services Change Guide (2018) Organisation Development and Design, ... -
Understanding cisplatin resistance using cellular models.
(John Wiley, 2007)Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ... -
Understanding How Incentives Influence Motivation and Retention of Health Workers
(IGI Global, 2011)A critical factor in addressing the human resources crisis in low and middle income countries (LMIC) is the ability to recruit, motivate and retain health workers. Failure in this area is one of the main causes of decline ... -
Understanding lived experiences and contextual realities of Ebola outbreaks: A case studies approach in Western Uganda
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2018)Ebola Virus Disease (EVD) is caused by a highly infectious and fatal filovirus of zoonotic origin among human and primate populations on the African continent. EVD is classified as a potential ?public health emergency of ... -
Understanding the Role of IL-36 Family Cytokines in Paediatric IBD
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)Despite significant therapeutic advances, the global incidence of Inflammatory Bowel Diseases (IBD) continues to rise, with approximately 25% of these cases reported in childhood and adolescence. Aberrant CD4+ TΗ cell ... -
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic adenocarcinoma (PDAC) is a lethal malignancy with a poor survival rate. One main challenge regarding PDAC is resistance to chemotherapy and radiotherapy. Therefore, there is an urgent requirement to characterise ... -
Understanding volunteer community health worker motivation : a longitudinal cohort study in Sierra Leone
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2014)Governments and non-profit organisations are once again turning to alternative cadres of health workers in an effort to accelerate health targets and address the severe global shortage of human resources for health. In low ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
(2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ... -
UNICORN; Underlying mechanisms in Neonatal Immune Metabolic Dysregulation and Brain Injury
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Neonatal encephalopathy (NE) is a clinically defined syndrome of disturbed neurologic function, in the earliest days of life. NE has a multifactorial aetiology and causes significant mortality and neurological ... -
Unlocking the treasure trove: From genes to schizophrenia biology
(2014)Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function ... -
Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis
(2015)Female reproductive tract tuberculosis is rarein the developed world and its diagnosis ischallenging. However, this case illustrates theimportance of including female reproductivetract tuberculosis in the differential for ...