Browsing School of Medicine by Title
Now showing items 1849-1868 of 3149
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Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 ... -
Magnetic Resonance Imaging Radiomics - Towards the Personalisation of Radiation Therapy for Prostate Cancer.
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2020)The primary function of a predictive biomarker is to accurately determine the outcome of a specified treatment. Radiomics is a developing field that involves advanced image analysis and high throughput extraction of ... -
Making healthcare accessible for single adults with complex needs experiencing long-term homelessness: A realist evaluation protocol
(2021)Background: Over the last several years, homelessness has increased in Ireland and across Europe. Rates have recently declined since the coronavirus disease 2019 (COVID-19) pandemic, but it is unclear whether emergency ... -
Making MECC Work: Enhancing the implementation of the National Making Every Contact Count Programme in Ireland
(University of Galway, 2022)Increasing chronic disease is a key societal challenge: Rapidly increasing rates of chronic disease are a key global societal challenge; The successful prevention and management of chronic disease is critically important ... -
Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
"Managed competition" for Ireland? The single versus multiple payer debate
(2014)A persistent feature of international health policy debate is whether a single-payer or multiple-payer system can offer superior performance. In Ireland, a major reform proposal is the introduction of 'managed competition' ... -
Management of gastro-bronchial fistula complicating a subtotal esophagectomy: a case report
(BioMed Central, 2009)Background The development of a fistula between the tracheobronchial tree and the gastric conduit post esophagectomy is a rare and often fatal complication. Case presentation A 68 year old man underwent radical ... -
Management of maternal HIV-1 infection in pregnancy : the experience of the GUIDE clinic
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)As of the end of 2007 there were an estimated 33.2 (30.6-36.1) million people worldwide living with HIV-1 or AIDS. Almost seven thousand new infections occurred ever day in 2007. Children under 15 years of age accounted ... -
Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition
(BioMed Central, 2009)We report herein a case of a synchronous presentation of an adenocarcinoma of esophagago-gastric junction type II and an ampullary tumor that was treated by combined Whipple's pancreaticoduodenectomy, total gastrectomy and ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
(2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis.
(2014)Objectives. ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work ... -
Market competition in European hospital care
(World Health Organisation, 2009)This chapter investigates some elements of market competition in European hospital care. We use the term market competition as a broad concept, covering a diverse and hard to demarcate range of changes or reforms, such ... -
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
(2022)Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the ... -
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects
(2014)BACKGROUND: Low maternal choline intake and blood concentration may be risk factors for having a child with a neural tube defect (NTD); however, the data are inconsistent. This is an important question to resolve because ...
