Browsing School of Medicine by Title
Now showing items 1247-1266 of 3151
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Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling
(The Company of Biologists Ltd, 2015)Globoid cell leukodystrophy (Krabbe disease) is a rare infantile neurodegenerative disorder. Krabbe disease is caused by deficiency in the lysosomal enzyme galactocerebrosidase (GALC) resulting in accumulation, in the ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Gastrointestinal manifestations in a patient with common variable immunodeficiency syndrome.
(2019)A 57 yo male with a background history of common variable Immunodeficiency syndrome (CVID) on Immunoglobulin Infusion (Kiovig) 40mg three weekly was referred for investigation of diarrhoea and follow up from previous history ... -
Gender and Neonatal Inflammation in Preterm Outcome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2021)Introduction: Preterm neonates are at high risk of sepsis and sepsis-related complications. Despite the prominence of sepsis in neonatal practice, there is no consensus definition and the role of organ dysfunction in ... -
Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium/endothelium interface.
(2014)The initial stages of the interaction between the host and Aspergillus fumigatus at the alveolar surface of the human lung are critical in the establishment of aspergillosis. Using an in vitro bilayer model of the alveolus, ... -
Gene expression profiling in patients with severe sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
(The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk
(2011)Objective: Dyslipidemia is a key feature of the metabolic syndrome (MetS), which is determined by both genetic and dietary factors. Methods: We determined relationships between ApoA1 and ApoB polymorphisms and MetS risk, ... -
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
(2011)Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ... -
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
(2014)BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify ... -
General Practice Referral Letters 'Tell me what you want'
(2007)Background: Good quality referral letters are an essential part of good clinical care and act as the interface between healthcare professionals in Primary and Secondary care. The letters should have enough information to ... -
General practitioner workforce planning: assessment of four policy directions
(2010)Background: Estimating the supply of GPs into the future is important in forecasting shortages. The lengthy training process for medicine means that adjusting supply to meet demand in a timely fashion is problematic. This ... -
Generalist solutions to complex problems: Generating practice-based evidence - The example of managing multi-morbidity
(2013)Background A growing proportion of people are living with long term conditions. The majority have more than one. Dealing with multi-morbidity is a complex problem for health systems: for those designing and implementing ... -
Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature
(2013)NTRODUCTION: Inherent and acquired cisplatin resistance reduces the effectiveness of this agent in the management of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms underlying this process may ... -
The Generation and Characterisation of Novel Mouse Models of Haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Haemophilia A (HA) is a hereditary, X-linked recessive disease caused by mutations in the F8 gene, with the absence or deficiency in the coagulation factor, Factor VIII (FVIII), resulting in a bleeding diathesis. The ... -
Generation of sinapinic-acid containing extracts from irish rapeseed meal and characterisation of their bioactive properties for potential human health applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Rapeseed is one of the world’s major oilseeds, and Europe is the largest producer. During the extraction of the oil, a low economic- value by-product, rapeseed meal, is produced. Rapeseed meal is ordinarily used as an ... -
Genes predict village of origin in rural Europe.
(2010)The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate ... -
Genetic analysis of the human prohibitin gene (PHB) in breast and other cancers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Prohibitin, an evolutionarily conserved gene situated on chromosome 17q21, was originally identified as a gene with antiproliferative properties. Studies of a Japanese population have shown prohibitin to be somatically ...