Surgery: Recent submissions
Now showing items 1-20 of 176
-
Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with ... -
Integrative multi-omic analytics for the early detection of pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic cancer (PC) has the lowest 5-year survival rate of any cancer, at just 12% in 2023. The poor survival rates observed in this cancer are the result of an accumulation of shortcomings and gaps in many aspects of ... -
Combination radiotherapy and immunotherapy: effects on the immune landscape of oesophageal adenocarcinoma and the multimodal therapeutic paradigm
The incidence of cancer of the oesophagus and the gastro-oesophageal junction (GEJ) has increased exponentially in the western world over the last half century. Oesophageal adenocarcinoma (OAC) is now the dominant subtype, ... -
End-Of-Life Decision Making A Novel Entrustable Professional Activity?
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Introduction: Making tough decisions about End-Of-Life situations and palliative care in acute surgical scenarios is a non-technical skill surgeons have to master over a number of years of experience. Data suggests that ... -
Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review
(2022)Background: Dysphagia is prevalent in oesophageal cancer with significant clinical and psychosocial complications. The purpose of this study was i) to examine the impact of exercise-based dysphagia rehabilitation on clinical ... -
ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol
(2021)Background: Exercise rehabilitation programmes, traditionally involving supervised exercise sessions, have had to rapidly adapt to virtual delivery in response to the coronavirus disease 2019 (COVID-19) pandemic to minimise ... -
To survive or to thrive: An investigation into fatigue and associated factors on surgical performance
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Background The issue of fatigue has been long-standing in the profession of surgery. Typically the term has been associated with performance decrement, and in particular, focus has been on mitigating fatigue to prevent ... -
Gone in 60 days: our first experience with a bioconvertible IVC filter
(Springer Science and Business Media LLC, 2021)The Sentry bioconvertible IVC filter (Boston Scientific, MA, USA) contains a bioabsorbable filament which hydrolyses after 60 days, allowing the arms of the filter to spring open, retract into the vessel wall and endothelialise, ... -
In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Title In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic. Introduction Magnetic resonance (MR) and computed tomography (CT) direct ... -
The Clinical Applications of Serum and Urinary Biomarkers in Prostate Cancer
(2020)At every stage of the prostate cancer journey from screening and diagnosis to management of advanced disease, patients and clinicians face dilemmas and decisions that can impact long-term outcomes. Although traditional ... -
The Clinical Applications of Tissue Biomarkers in Prostate Cancer
(2020)The clinical course of localized prostate cancer varies widely, from indolent disease unlikely to need treatment to aggressive disease requiring intensive, multimodal therapy. Traditionally, treatment decisions have been ... -
Endovascular management of delayed upper gastrointestinal bleeding after open esophagectomy for a benign oesophageal stricture
(2021)Introduction: Delayed upper gastrointestinal (GI) bleeding is a rare complication of esophagectomy and can be difficult to manage. Presentation: A 76-year-old female represented 17 days post open esophagectomy ... -
Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue
(2020)Background and aim: Ulcerative colitis (UC) is an autoimmune disease characterized by inflammation in the gastrointestinal tract. The severity of UC is higher in nonsmokers than smokers; however, the biological mechanisms ...