Browsing Surgery by Title
Now showing items 92-111 of 176
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LC3B globular structures correlate with survival in esophageal adenocarcinoma
(2015)Background Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients ... -
Leptin and adiponectin receptor expression in oesophageal cancer.
(2014)BACKGROUND: Oesophageal adenocarcinoma is an exemplar model of an obesity-associated adenocarcinoma. Altered secretion of adipokines by visceral fat is believed to play a key role in tumorigenesis. This study examined ... -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
(2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
(2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
Local and systemic inflammation in oesophageal disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ... -
Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery.
(2010)Background: The association between cancer, major surgery and venous thromboembolism (VTE) is well established. Multimodal therapy is increasingly being used as standard treatment for localised gastrointestinal ... -
Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
Management of gastro-bronchial fistula complicating a subtotal esophagectomy: a case report
(BioMed Central, 2009)Background The development of a fistula between the tracheobronchial tree and the gastric conduit post esophagectomy is a rare and often fatal complication. Case presentation A 68 year old man underwent radical ... -
Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition
(BioMed Central, 2009)We report herein a case of a synchronous presentation of an adenocarcinoma of esophagago-gastric junction type II and an ampullary tumor that was treated by combined Whipple's pancreaticoduodenectomy, total gastrectomy and ... -
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a -/- mutants
(2011)Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome ... -
Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study
(2019)Background: Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant ... -
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
(American Association for Cancer Research, 2002)Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth, metastasis, and angiogenesis of prostate cancer. The ... -
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ... -
MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma
(2015)Oesophageal adenocarcinoma (OAC) is the sixth most common cause of cancer deaths worldwide, and the 5-year survival rate for patients diagnosed with the disease is approximately 17%. The standard of care for locally advanced ... -
Midgut pain due to an intussuscepting terminal ileal lipoma: a case report.
(2010)ABSTRACT: INTRODUCTION: The occurrence of intussusception in adults is rare. The condition is found in 1 in 1300 abdominal operations and 1 in 100 patients operated for intestinal obstruction. The child to adult ratio is ... -
Mitochondrial dysfunction during disease progression in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ... -
Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
(2012)Background: To examine the association between mitochondrial mutagenesis and the proinflammatory microenvironment in patients with inflammatory arthritis. Methods: Fifty patients with inflammatory arthritis underwent ... -
Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ...