Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Subject "Enzyme inhibitors"
Now showing items 1-2 of 2
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Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
(2010)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...