Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Author "GILMER, JOHN"
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A Central Role for Monocyte-Platelet Interactions in Heart Failure
GILMER, JOHN (2015)Heart failure (HF) is an increasingly prevalent and costly multifactorial syndrome with high morbidity and mortality rates. The exact pathophysiological mechanisms leading to the development of HF are not completely ... -
Matrix metalloproteinases in inflammatory bowel disease: an update
GILMER, JOHN; MEDINA MARTIN, CARLOS (2015)Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets.
GILMER, JOHN (2012)Objectives Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple pharmacological ... -
N-subsituted homopiperazine barbiturates as gelatinase inhibitors
RADOMSKI, MAREK; WANG, JUN; MEDINA MARTIN, CARLOS; GILMER, JOHN (2011)Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as ... -
Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer's Disease
GILMER, JOHN (2016)sosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be ...