Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Title
Now showing items 52-71 of 445
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A Central Role for Monocyte-Platelet Interactions in Heart Failure
(2015)Heart failure (HF) is an increasingly prevalent and costly multifactorial syndrome with high morbidity and mortality rates. The exact pathophysiological mechanisms leading to the development of HF are not completely ... -
Characterisation and fundamental insight into the formation of new solid state, multicomponent systems of propranolol.
(2021)The physiochemical properties of acidic or basic active pharmaceutical ingredients (APIs) can be optimised by forming salts with different counterions. The aim of this work was to synthesise a novel salt of propranolol ... -
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)Background: There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere?) represents the most active chemotherapeutic agent it only gives a modest survival ... -
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ... -
Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts
(Frontiers, 2019)Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine.Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected groupof compounds ... -
Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: An asian herbal medicine
(2019)Crataegus almaatensis, an endemic ornamental plant in Kazakhstan is used in popular medicine due to its cardiotonic properties. The most studied species of the same genus are commonly found in Europe, which shows the ... -
Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia
(2014)Leukemia is an immediately life-threatening cancer wherein immature blood cells are overproduced, accumulate in the bone marrow (BM) and blood and causes immune and blood system failure. Treatment with chemotherapy can ... -
Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose
(2015)PURPOSE: To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
(2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
Collaborative pharmaceutical care in an Irish hospital: uncontrolled before-after study
(2014)Background We investigated the benefits of the Collaborative Pharmaceutical Care in Tallaght Hospital (PACT) service versus standard ward-based clinical pharmacy in adult inpatients receiving acute medical care, particularly ... -
Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation
(2016)In the present study, in vitro permeation experiments in a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine (RV) transdermal drug delivery system. ... -
A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
(2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ...