Browsing Dental Science (Scholarly Publications) by Author "MORAN, GARY"
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AVIAN-ASSOCIATED AND HUMAN ISOLATES OF Candida dubliniensis ARE GENETICALLY DISTINCT
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY; MCMANUS, BRENDA (2009)When Candida dubliniensis isolates obtained from seabird excrement and from humans in Ireland were compared by using multilocs sequence typing, 13 of 14 avian isolates were genetically distinct from human isolates. The ... -
CANDIDA ALBICANS VERSUS CANDIDA DUBLINIENSIS: WHY IS C. ALBICANS MORE PATHOGENIC?
COLEMAN, DAVID; SULLIVAN, DEREK; MORAN, GARY (2012)Candida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection ... -
Candida dubliniensis: An update
SULLIVAN, DEREK; SHANLEY, DIARMUID; MCCARTAN, BERNARD; MORAN, GARY; COLEMAN, DAVID (1999)The increased incidence of fungal infections during the last decade has been well-documented. Given that one of the most important factors contributing to this phenomenon is the increased numbers of immunocompromised ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
COLEMAN, DAVID; MORAN, GARY; SULLIVAN, DEREK (2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
COMPARATIVE GENOMICS USING CANDIDA ALBICANS DNA MICROARRAYS REVEALS ABSENCE AND DIVERGENCE OF VIRULENCE ASSOCIATED GENES IN CANDIDA DUBLINIENSIS
SULLIVAN, DEREK; MORAN, GARY; COLEMAN, DAVID (2004)Candida dubliniensis is a pathogenic yeast species closely related to Candida albicans. However, it is less frequently associated with human disease and displays reduced virulence in animal models of infection. We have ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
COLEMAN, DAVID; MORAN, GARY; SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (Blackwell Publishing, 2007-09)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. ... -
An in vivo comparison of bacterial microleakage in two dental implant systems: identification of a pathogenic reservoir in dental implants
MORAN, GARY (2015)Objectives. The aim of this study was to compare internal bacterial colonization in two implant systems, one screw root form (SRF) with an external hexagon connection and one plateau root form (PRF) with a Morse taper ... -
MICROBIOLOGICAL SCREENING OF IRISH AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY (APECED) PATIENTS REVEALS PERSISTENCE OF CANDIDA ALBICANS STRAINS, GRADUAL REDUCTION IN SUSCEPTIBILITY TO AZOLES AND INCIDENCES OF CLINICAL SIGNS OF ORAL CANDIDIASIS WITHOUT CULTURE EVIDENCE
MCMANUS, BRENDA; MORAN, GARY; FLEMING, PADRAIG; COLEMAN, DAVID; HEALY, CLAIRE; NUNN, JUNE; SULLIVAN, DEREK (2011)Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) are prone to chronic mucocutaneous candidiasis, which is often treated with azoles. The purpose of this study was to characterize the ... -
MULTILOCUS SEQUENCE TYPING REVEALS THAT THE POPULATION STRUCTURE OF Candida dubliniensis IS SIGNIFICANTLY LESS DIVERGENT THAN THAT OF Candida albicans
SULLIVAN, DEREK; MORAN, GARY; COLEMAN, DAVID; MCMANUS, BRENDA ANN (2008)he pathogenic yeast Candida dubliniensis is phylogenetically very closely related to Candida albicans, and both species share many phenotypic and genetic characteristics. DNA fingerprinting using the species-specific probe ... -
A Ser29Leu SUBSTITUTION IN THE CYTOSINE DEAMINASE Fca1p IS RESPONSIBLE FOR CLADE-SPECIFIC 5-FLUCYTOSINE RESISTANCE IN Candida dubliniensis
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY; MCMANUS, BRENDA ANN (2009)The population structure of the opportunistic yeast pathogen Candida dubliniensis is composed of three main multilocus sequence typing clades (clades C1 to C3), and clade C3 predominantly consists of isolates from the ... -
Telomeric ORFs (TLOs) in Candida spp. encode Mediator subunits that regulate distinct virulence traits
MORAN, GARY; SULLIVAN, DEREK (2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. albicans ... -
Telomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?
MORAN, GARY; SULLIVAN, DEREK (2015)Recent studies of fungal genomes have shown that subtelomeric regions of chromosomes are areas of rapid evolution that facilitate adaptation to novel niches [1]. Several years ago, analysis of the genome of the human ... -
Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis
MORAN, GARY (2012)Hyphal growth is repressed in Candida albicans and C. dubliniensis by the transcription factor Nrg1. Transcript profiling of a C. dubliniensis NRG1 mutant identified a common group of 28 NRG1 repressed genes in both species, ... -
Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points
DUNCAN, HAL; MORAN, GARY; FLEMING, GARRY (2015)Dental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental ... -
Triclosan antagonises fluconazole activity against Candida albicans
MORAN, GARY (2012)Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, ...