Browsing Haematology (Scholarly Publications) by Subject "Clinical medicine"
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ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
(2006)ADAMTS13 controls the multimeric size of circulating von Willebrand factor (VWF) by cleaving the Tyr1605?Met1606 bond in theA2 domain. To examine substrate recognition, we expressed in bacteria and purified three A2 ... -
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
(2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Multifunctional specificity of the protein C/activated protein C Gla domain.
(American Society for Biochemistry and Molecular Biology, 2006)Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein ...