Browsing Chemistry (Theses and Dissertations) by Author "Fernandez, Sergio Lopez"
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Synthesis of nitropyrimidines as inactivators of 0-6-Methylguanine-DNA Methyltransferase
Fernandez, Sergio Lopez (Trinity College (Dublin, Ireland). School of Chemistry, 2009)The cytotoxic effects of the chemotherapeutic N-(2-chloroethyl)-N-nitrosoureas (e.g. BCNU, CCNU, fotemustine) and the related methylating agents (e.g. DTIC, procarbazine, temozolomide) are primarily a consequence of their ...