Browsing Chemistry (Theses and Dissertations) by Title
Now showing items 338-357 of 394
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Tailored nitrogen-containing polyaromatics - from surfaces to stacks
(Trinity College (Dublin, Ireland). School of Chemistry, 2016)Chapter 1: This chapter gives a broad introduction to the subjects of graphene and nanographenes, which are discussed in subsequent chapters. Common methodologies for the synthesis of substituted polyphenylenes and ... -
The Tamura Cycloaddition: Mechanism and Enantiocontrol
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)This thesis documents attempts to employ succinimide derivatives as ‘anhydride surrogates’ in the organocatalytic cycloaddition between aryl succinic anhydrides and various electrophiles previously developed in our research ... -
Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Research on the design and synthesis of DNA targeting molecules is widespread. There are a number of diseases which are treated using DNA-targeting agents. DNA ligands have been shown to exhibit anticancer, antiprotozoal, ... -
Targeting Synthetic Advances in Extended Phenanthrene and Phenanthroline Systems
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)The work herein describes the synthesis of a number of extended phenanthrene and phenanthroline systems as ligands, their Ru(II) and Ir(III) metal complexes, nitrogen-substituted graphene nanoribbons (N-GNRs), and as ... -
Teaching old dogs new tricks : transition metal-catalysed reactions for generation of rigid cubane and designer porphyrin scaffolds
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The aim of this work was to use Pd-catalysis in the pursuit of novel, synthetically interesting, structural scaffolds based around either the rigid cubane framework or the optically active porphyrinoid core. In both cases, ... -
Templated synthesis of novel molecules and materials using 1,4-disubstituted-1,2,3-triazole supramolecular building blocks
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)This thesis, entitled "Templated synthesis of novel molecules and materials using 1,4-disubstituted-1,2,3-triazole supramolecular building blocks", describes the facile synthetic modification of the 1,4-disubstituted-1,2 ... -
The adsorption of amines and other small molecules on platinum surfaces
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)This thesis presents an investigation of the adsorption and thermal decomposition of methylamine, dimethylamine, trimethylamine and s-triazine on Pt(110) and carbon monoxide, nitric oxide and nitrous oxide on Pt(331) using ... -
The adsorption of simple amines on platinum surfaces
(Trinity College (Dublin, Ireland). School of Chemistry, 2001)This thesis presents the results of an investigation of the adsorption of methylamine, dimethylamine, trimethylamine and ethylenediamine on Pt(111) and Pt(331). The chemical composition and geometric structure of the clean ... -
The chemistry and photochemistry of Ru(II) bipyridyl carbonyl complexes incorporated in Nafion
(Trinity College (Dublin, Ireland). School of Chemistry, 1991)The chemical reactions of bis(bpy)carbonylruthenium complexes, catalysts for the water gas shift reaction, have been investigated under mild conditions in Nafion, an ionic polymer. Chemical and photochemical reactions ... -
The chemistry of beta-Sulfonylenamines
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)Many reactions of alkenes and enamines with various different reagents have been studied in the past and numerous books dealing with the chemistry of these compounds have been published. This project aims to find out how ... -
The chemistry of the Uranyl Moiety
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)Uranium has had a "Jekyll and Hyde" reputation for many years, stemming from its ability to both create clean and cheap energy and from its ability to create powerful and dangerous weapons. This Thesis examines the chemistry ... -
The design of artificial enzymes, novel chiral organocatalysts and new ligation technologies
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)An investigation into the mode of action of aldehyde dehydrogenase enzymes was undertaken through the synthesis of a series of compounds that were hypothesised as potential biomimetics. This study revealed the possible ... -
The design of biofunctional cinchona alkaloid derived catalysts : a new departure
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)This thesis reports the synthesis of a novel class of quinine derived catalyst and its application to the field of organocatalysis. Initially, a suite of seven novel C-9 phenol and naphthol substituted quinine derivatives ... -
The design, synthesis and application of (thio)urea-based organocatalysts for a range of C-C bond transformations
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The identification and development of small chiral organic molecules capable of mimicking the hydrogen-bonding capabilities of enzymes is the main thrust of this thesis concerning the design and application of new (thio)urea ... -
The design, synthesis and evaluation of aryl guanidinium derivatives as α2 adrenoceptor antagonists for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Depression is among the leading causes of illness worldwide and is predicted to be the single largest contributor by 2020. Antidepressants are the most effective treatment but current drugs have slow onset of effects and ... -
The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)Over the past three decades, the synthesis of enantiomerically pure products became a major concern in modem research. In this context, organocatalysis has emerged as a viable method and interest in this field has intensified ... -
The development of novel methodologies for the selective Tischenko reaction and the use of acylpyrazoles as directing groups in organocatalytic 1,4-conjugate addition reactions
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)Summary [end of chapter 1, page 59] Though significant advances in the field of organocatalytic Michael addition reactions have been achieved through the enantioselective additions of pronucleophiles to, in the main, ... -
The development of novel organocatalysts for asymmetric methylene transfer in the Corey-Chaykovsky reaction
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)To date, the enantioselective preparation of terminal three-membered heterocycles via the Corey-Chaykovsky (CC) reaction has been characterised by unsatisfactory enantioselectivities. In the benchmark literature report ... -
The electroanalytical applications of carbon nanotube-modified electrodes
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)In this study, cyclic voltammetry, potential step chronoamperometry, batch amperometry, hydrodynamic voltammetry and electrochemical impedance spectroscopy were used to investigate the physical and chemical properties of ... -
The electromechanical properties of individual nanowires
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)The measurement of the mechanical and electrical properties of individual nanowires and nanowire systems is of paramount importance for their future incorporation into functional devices. An equally important property that ...