Browsing Chemistry (Theses and Dissertations) by Title
Now showing items 51-70 of 395
-
Conductance probe microscopy investigation on the local electronic properties of single walled carbon nanotube systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)In order to build electronic devices and circuits comprised of nanoscale materials as the active element it is imperative to unravel the local electronic properties of these materials. We have performed an in-depth study ... -
Conformational control of cofactors in nature : the influence of protein induced macrocycle distortion on the biological function of tetrapyrroles in photosynthesis
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)This thesis details new research into the influence of nonplanar distortions upon the function of porphyrin based cofactors in proteins via analysis of structural data deposited in the Protein Data Bank (PDB) combined with ... -
Conformationally restricted and Bis-aryl guanidinium derivatatives : towards imroved Alpha2-adrenergic affinity and antagonism for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The evident necessity to develop novel therapeutics to treat depression has been recently highlighted by the World Health Organisation who has listed depression to be the second largest global health burden by the year ... -
Controlling the carbon-bio interface: ex-situ and in-situ studies of fundamental biomolecule--carbon reactions
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2017)Carbon materials and nanomaterials are of great interest for biological applications such as implantable apparatus and nanoparticle vectors. In particular, amorphous carbon is extensively used as coating for biomedical devices ... -
Coordination and hydrogen bonded networks featuring 4,4'-dicarboxy-2,2'-bipyridine
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)The research presented in this thesis lies within the general area of supramolecular and coordination chemistry. More specifically, this project involves the study of 4,4'-dicarboxy-2,2'-bipyridine (4,4'-H2dcbp) as a linker ... -
Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Crystal Engineering Study of Porphyrins, DPMs, BODIPYs, and Cubanes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)This thesis consists of three topics, each covering an aspect of crystal engineering: for porphyrins (Chapter 1), BODIPYs and tris(dipyrrinato)metal(III) complexes (Chapter 2), and cubanes (Chapter 3). Each chapter contains ... -
Cubane and Triptycene as Scaffolds in the Synthesis of Porphyrin Arrays
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)The primary aim of this research was to synthesise multichromophoric arrays that are linked through rigid isolating units with the capacity to arrange the chromophores in a linear and fixed orientation. The electronically ... -
Cyclen-based lanthanide complexes as ribonuclease mimics
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)This thesis, entitled "Novel Cyclen-based Lanthanide Complexes as Ribonuclease Mimics" is divided into six chapters. Chapter One introduces the field of mRNA cleavage, with emphasis on the hydrolysis of phosphodiesters. ... -
Design and characterization of functional interfaces for fundamental studies of nitro-polycyclic aromatic hydrocarbon chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)Nitro-polycyclic hydrocarbons (nPAHs) are a class of highly mutagenic compounds whose reactions and fates in the atmosphere have a tremendous effect on atmospheric chemistry. In the troposphere, the photodegradation of ... -
Design and development of novel self-assembled luminescent lanthanide complexes in solution and in soft materials
(Trinity College Dublin. School of Chemistry. Discipline of ChemistrySchool of Chemistry, 2017)This thesis describes the design, synthesis and characterisation of naphthyl-dipicolylamide (naphthyl-dpa) ligands for sensitisation of lanthanide, Ln(III), emission. Chapter 1 provides an introduction to the fundamental ... -
Design and synthesis of DMAP-derived organocatalysts for enantioselective induction
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)The development of small organic molecules capable of mimicking enzymatic action (in an asymmetric catalysis context) is a challenge that is receiving widespread attention in contemporary organic chemistry. Herein we report ... -
Design and Synthesis of Meso- and Macrocyclic Tripodal Triamine Ligands and Investigations into their Coordination Chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 2017)The ability to directly and selectively functionalise hydrocarbons is one of the greatest remaining challenges facing chemists. The development of catalytic systems capable of affecting these transformations under ambient ... -
Design and Synthesis of Terpyridine Functionalised Supramolecular Architectures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Coordination-driven supramolecular assembly is an extremely useful tool to generate architectures of increased complexity and functionality, such as metallo-supramolecular gels and emissive materials. Interest in the ... -
Design of a novel family of bifunctional phase-transfer catalysts and their applications in the kinetic resolution of 2-oxindole derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The design and synthesis of a biomimetic organocatalyst mimicking the active site of aspartate proteases have been undertaken. The design was aimed at constructing an artificial enzyme bearing two carboxylic acid groups ... -
The Design of Ruthenium and Iridium Triplet Photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)This thesis describes compounds designed to harness the energies of photon-induced transitions between electronic energy levels. Applications that involve such transitions include but are not limited to photodynamic therapy, ... -
Design, synthesis and pharmacological evaluation of novel heterocyclic guanidine derivatives as alpha₂-adrenoceptor antagonists for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Messages travel through the brain and nervous system in two ways, the first is in the form of an electrical impulse, called an action potential, which travels along a cell called a neuron. The second is via a chemical ... -
Design, synthesis and photophysical evaluation of novel 1 ,8-naphthalimide Tröger's base derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled 'Design, Synthesis and Photophysical Evaluation of Novel 1,8- Naphthalimide Based Troger's Bases' is divided into five chapters. The first chapter provides a brief description of the structure of DNA ... -
Design, synthesis and photophysical evaluation of novel luminescent sensing devices : from anion sensors to heteroditopic receptors
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)This thesis entitled "Design, Synthesis and Photophysical Evaluation of Novel Luminescent Sensing Devices: From Anion Sensors to Heteroditopic Receptors" is divided into six chapters. Chapter 1, the introduction, is divided ... -
Design, synthesis and physical evaluation of luminescent lanthanide-based supramolecular systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)This thesis entitled "Design, Synthesis and Physical Evaluation of Luminescent Lanthanide-based Supramolecular Systems" is divided into five chapters, and is in two parts. The first part. Chapter 2, deals with the synthesis ...