Browsing Chemistry (Theses and Dissertations) by Title
Now showing items 318-337 of 395
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Synthesis of some 8-Aza-7-deazaguanines as potential inactivators of Atase
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)Certain cancer chemotherapeutic agents act by alkylating the O6-position of guanine residues in DNA. This lesion can ultimately cause the death of the targeted cancer cells. However, the efficacy of the cytotoxic effect ... -
Synthesis of some homochiral-2aminopyridine N-oxides as potential chiral hypernucleophilic acylation catalysts
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis is concerned with the study and attempted synthesis of an array of homochiral pyridines and their N-oxides and their ultimate use as potential hypernucleophilic promoters of the acylation of a variety of racemic ... -
Synthesis of Transition Metal Dichalcogenides from Solid-Phase Precursors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Interest in telluride tranisition metal dichalcogenides (TMDs) has until very recently, lagged far behind that of more common TMDs such as MoS2. There are a number of potential reasons for this, such as these materials not ... -
Synthesis, biological evaluation and subsequent SAR of four novel families of alkyliphatic twin drugs
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)The I2-IBS is a well known binding site widely distributed in the body of both animals and humans. It is suspected that they are an allosteric binding site of MAO-B. They have also been linked to several conditions such ... -
Synthesis, biophysical and biochemical studies of new guanidine-like derivatives targeting DNA
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The literature describes many DNA minor groove binders, some of them having similar characteristics such as crescent shape, being dicationic and containing hydrogen bond donating or accepting groups. -
Synthesis, characterisation and applications of chiral nanoparticles
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)The main aim of this thesis is to develop and investigate novel chiral nanomaterials, as well as explore potential applications that would exploit the chirality. Chapter 1 details a general introduction to nanotechnology, ... -
Synthesis, characterization and activity evaluation of novel spiropyran-based ion sensors
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Photochromism indicates a reversible transformation of a single chemical species induced in one or both directions by electromagnetic radiation between two states having different absorption spectra. Photochromic compound ... -
Synthesis, functionalization and applications of silver nanoparticles
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The aim of the work described in this thesis is to investigate various different methods for synthesis, functionalization and surface-enhanced Raman spectroscopy applications of silver nanoparticles. -
The synthesis, photophysical and biological evaluation of glycosylated naphthalimides for medicinal and material applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)This thesis entitled ‘Synthesis, Photophysical and Biological Evaluation of Glycosylated Naphthalimides for Medicinal and Materials Applications’ is divided into 8 chapters, in which Chapter 1, the introduction, gives an ... -
Synthesis, photophysical and DNA binding studies of novel pyridinium based 1 ,8-naphthalimide derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled "Synthesis, Photophysical and DNA Binding Studies of Novel Pyridinium Based 1,8-Naphthalimide Derivatives" is divided into six chapters. Chapter 1 is the introductory chapter, which provides a brief ... -
Synthesis, reactivity and modification of novel meso-substituted porphyrins
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)The aim of this work was the synthesis, modification and characterisation of novel meso- substituted porphyrins. In particular, focus was directed towards the development of new synthetic pathways and the improvement of ... -
Synthesis, structural studies and physicochemical properties of hybrid inorganic-organic materials : novel materials based on iminodiacetic acid substituted aromatic ligands
(Trinity College (Dublin, Ireland). School of Chemistry, 2011) -
Synthetic and spectroscopic studies of novel nonplanar tetrapyrrolic macrocycles
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The aim of this work was to develop a new synthetic route for the synthesis of hydroporphyrins and to investigate their photophysical properties. A second aim was to investigate the effect of protonation on the conformation ... -
Synthetic Approaches to Light-Harvesting Materials Containing Earth-Abundant Metals
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)In this thesis, entitled Synthetic Approaches to Light-Harvesting Materials Containing Earth-Abundant Metals, a crystal engineering approach is taken to investigate two kinds of materials, namely coordination polymers based ... -
Synthetic Approaches to Metal-Organic Frameworks and Coordination Cages Incorporating Heterocycle-Based Linkers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)This thesis, entitled Synthetic Approaches to Metal-Organic Frameworks and Coordination Cages Incorporating Heterocycle-Based Linkers, focuses on the synthesis of metal-organic frameworks (MOFs) and coordination cages using ... -
Synthetic Approaches Towards 3rd Generation, Light-Harvesting Metal-Organic Frameworks for Photo-Electrocatalytic Energy Conversions
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Society?s increasing energy requirements as well as evident climate change problems present humanity with significant scientific challenges. Switching to more renewable energies sources such as the high density, carbon-free ... -
Synthetic Approaches towards Photoactive Metal-Organic Frameworks
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Metal-organic frameworks (MOFs) are a class of hybrid inorganic-organic materials. They are composed of metal-containing units linked by organic linkers through strong bonds, forming high dimensional frameworks. ... -
Synthetic investigations towards the preparation of novel tetracycline antibiotics
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)This research initially concerned itself with the synthesis of a dimeric compound of tetracycline antibiotics linked by a flexible tether. Tetracycline antibiotics have been in use since their discovery in the 1940s but ... -
Synthetic routes towards guanidines of biological interest
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)The Rozas laboratory has been interested in the synthesis and biological evaluation of guanidine containing molecules for the past ten years. The application of guanidines as both minor groove binders (MGB) and a2-adrenoceptor ... -
Synthetic studies for photo-triggered release of bioconjugate porphyrin photosensitisers in photodynamic therapy
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The objective of this research was to synthesise porphyrin linked-bioconjugate photosensitisers that can be released upon irradiation with UV light; aiming to improve photodynamic cancer therapy efficiency. This ...