Browsing Surgery (Scholarly Publications) by Author "Phelan, James"
Now showing items 1-6 of 6
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Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
Connon, Stephen; Reynolds, John; Lynam-Lennon, Niamh; Phelan, James; Maher, Stephen (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
Ravi, Narayanasamy; Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh; Phelan, James (2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Dunne, Margaret; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ... -
Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival
O'Sullivan, Jacintha; Mehigan, Brian; Mc Cormick, Paul; Phelan, James (2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
The role of inflammation in cancer of the esophagus.
Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Phelan, James (2014)Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. ...