Browsing Surgery (Scholarly Publications) by Author "Lysaght, Joanne"
Now showing items 1-15 of 15
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Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
Pidgeon, Graham; Lysaght, Joanne; O'Byrne, Ken; Gately, Kathy (2016)Background Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour ... -
Cooperation between chemotherapy and immunotherapy in gastroesophageal cancers
Lysaght, Joanne (2020)Gastroesophageal cancers (GOCs) represent some of the most common cancers globally and are linked with poor survival rates. The current standard of care includes multimodal chemotherapy, radiotherapy and surgery. However, ... -
Editorial: T cell alterations in adipose tissue during obesity, HIV, and cancer
Lysaght, Joanne (Frontiers Media, 2019-05-28)This collection of articles is designed to foster understanding of the variety and function of T cells in adipose from different species in different disease states. This work originally developed from the obesity epidemic. ... -
Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue
Lysaght, Joanne; O'Sullivan, Jacintha (2020)Background and aim: Ulcerative colitis (UC) is an autoimmune disease characterized by inflammation in the gastrointestinal tract. The severity of UC is higher in nonsmokers than smokers; however, the biological mechanisms ... -
Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
Lysaght, Joanne; Pidgeon, Graham; Lynam-Lennon, Niamh (2014)Background: Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients.
Long, Aideen; Lysaght, Joanne; Maher, Stephen (2018) -
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines
Lysaght, Joanne; Prina Mello, Adriele (2019)Although interest and funding in nanotechnology for oncological applications is thriving, translating these novel therapeutics through the earliest stages of preclinical assessment remains challenging. Upon intravenous ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
pSTAT3 levels have divergent expression patterns and associations with survival in squamous cell carcinoma and adenocarcinoma of the oesophagus
Reynolds, John; Lysaght, Joanne (2018) -
Radiation and immunotherapy in upper gastrointestinal cancers: The current state of play
Lysaght, Joanne; Reynolds, John (2021)Radiotherapy remains one of the contemporary cornerstones of cancer treatment in the neoadjuvant, curative, adjuvant and palliative settings, either in isolation or as a multimodal approach. Moreover, recent advances in ... -
Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity
Lysaght, Joanne; Reynolds, John (2021)Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating ... -
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Ravi, Narayanasamy (2020)Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however ... -
The role of inflammation in cancer of the esophagus.
Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Phelan, James (2014)Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. ... -
The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation.
Dunne, Margaret; Lysaght, Joanne; Reynolds, John (2020)Background: Only 10-30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ... -
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.
Lynam-Lennon, Niamh; Pidgeon, Graham; Lysaght, Joanne; Reynolds, John (2019)Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity ...