Browsing Surgery (Scholarly Publications) by Author "Lynam-Lennon, Niamh"
Now showing items 1-7 of 7
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Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
Connon, Stephen; Reynolds, John; Lynam-Lennon, Niamh; Phelan, James; Maher, Stephen (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma.
Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
Ravi, Narayanasamy; Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh; Phelan, James (2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
O'Sullivan, Jacintha; Pidgeon, Graham; Reynolds, John; Porter, Richard; Lynam-Lennon, Niamh (2014)Background Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
Lysaght, Joanne; Pidgeon, Graham; Lynam-Lennon, Niamh (2014)Background: Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
Dunne, Margaret; Lynam-Lennon, Niamh; O'Sullivan, Jacintha; Ravi, Narayanasamy (2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.
Lynam-Lennon, Niamh; Pidgeon, Graham; Lysaght, Joanne; Reynolds, John (2019)Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity ...