Browsing Zoology (Scholarly Publications) by Subject "Genes & Society"
Now showing items 1-10 of 10
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Abnormal notochord branching is associated with foregut malformations in the adriamycin treated mouse model.
(University of Edinburgh (datashare), 2011)Oesophageal atresia (OA) and tracheooesophageal fistula (TOF) are relatively common human congenital malformations of the foregut where the oesophagus does not connect with the stomach and there is an abnormal connection ... -
Effects of abnormal muscle forces on prenatal joint morphogenesis in mice
(2019)Fetal movements are essential for normal development of the human skeleton. When fetal movements are reduced or restricted, infants are at higher risk of developmental dysplasia of the hip and arthrogryposis (multiple joint ... -
Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo
(University of Edinburgh (datashare), 2009)Structures and features of the face, throat and neck are formed from a series of branchial arches that grow out along the ventrolateral aspect of the embryonic head. Multiple signaling pathways have been implicated in ... -
Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture.
(Springer Nature, 2022)Spatial and temporal control of chondrogenesis generates precise, species-specific patterns of skeletal structures in the developing vertebrate limb. The pattern-template is laid down when mesenchymal cells at the core ... -
Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways.
(University of Edinburgh (datashare), 2014) -
The importance of foetal movement for co-ordinated cartilage and bone development in utero : clinical consequences and potential for therapy.
(University of Edinburgh (datashare), 2015) -
Joint development recovery on resumption of embryonic movement following paralysis
(2021)Fetal activity in utero is a normal part of pregnancy and reduced or absent movement can lead to long-term skeletal defects, such as Fetal Akinesia Deformation Sequence, joint dysplasia and arthrogryposis. A variety of ... -
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation
(University of Edinburgh (datashare), 2020)Background: Normal skeletal development, in particular ossification, joint formation and shape features of condyles, depends on appropriate mechanical input from embryonic movement but it is unknown how such physical stimuli ... -
Mechanical Stimulation via Muscle Activity is Necessary for the Maturation of Tendon Multiscale Mechanics during Embryonic Development
(2021)During embryonic development, tendons transform into a hypocellular tissue with robust tensile load-bearing capabilities. Previous work suggests that this mechanical transformation is due to increases in collagen fibril ... -
WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data
(2022)Background: The spatio-temporal organisation of many biological processes such as gene-expression and neuronal activity is critical to understanding the overall biological behaviour, phenotype and disease. This is ...