Browsing Zoology (Scholarly Publications) by Author "Rolfe, Rebecca"
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Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape
Rolfe, Rebecca (2017)The incidence of congenital spine deformities, including congenital scoliosis, kyphosis, and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. ... -
Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint
Rolfe, Rebecca; Murphy, Paula (University of Edinburgh (datashare), 2018)Embryo movement is essential to the formation of a functional skeleton. Using mouse and chick models, we previously showed that mechanical forces influence gene regulation and tissue patterning, particularly at developing ...