Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells

EHRHARDT, CARSTEN; BAGINSKI, EVE LEONIE; BUCKLEY, STEPHEN

Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells

Files

The Stability of Salmon Calcitonin Against Trypsin, Chymotrypsin and Neutrophil Elastase in Human Lung Epithelial Cells.pdf (130.33 KB)

Date

2010

Authors

EHRHARDT, CARSTEN

BAGINSKI, EVE LEONIE

BUCKLEY, STEPHEN

Citation

L Baginski, ST Buckley, U Bakowsky, C Ehrhardt, Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells, Sci Pharm, 8th Central European Symposium on Pharmaceutical Technology, Graz, Austria, 16-18/09/2010, 78, 3, 2010, 720

Abstract

At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body. Here, we investigated how these proteinases affect drug disposition of sCT in the lungs.