Analysis of morphogenesis and chlamydospore formation by Candida albicans and Candida dubliniensis

Abstract

Candida dubliniensis is the species that is most closely related to Candida albicans. Despite their close phylogenetic relatedness, epidemiological and infection model data suggest that C. albicans is a far more successful pathogen. The reasons for this disparity in virulence are still unclear, however, it has been shown that C. dubliniensis is less able than C. albicans to produce hyphae under a wide range of in vitro and in vivo conditions. The purpose of this study was to investigate the comparative effects of glucose/galactose and methionine on morphogenesis in the two species.