Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK WILLIAMS

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.pdf (313.64 KB)

Date

2008

Authors

CORVIN, AIDEN

GILL, MICHAEL

MORRIS, DEREK WILLIAMS

Publisher

Nature Publishing Group

Citation

Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, Macintyre DJ, Maclean AW, St Clair D, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Nicol Ferrier I, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH; Wellcome Trust Case Control Consortium, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N `Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder? in Nature Genetics, 40, (9), 2008, pp 1056 - 1058

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.